منابع مشابه
Biological basis for human capacitation.
More than 50 years ago Austin and Chang defined mammalian sperm capacitation as a period of time that sperm must reside in the female reproductive tract before they acquire the ability to fertilize oocytes. Since then numerous investigations have attempted to more clearly define the molecules and processes that are a part of capacitation. The data that have provided a more clear definition of c...
متن کاملBiological basis for human capacitation
More than 50 years ago Austin and Chang defined mammalian sperm capacitation as a period of time that sperm must reside in the female reproductive tract before they acquire the ability to fertilize oocytes. Since then numerous investigations have attempted to more clearly define the molecules and processes that are a part of capacitation. The data that have provided a more clear definition of c...
متن کاملThe molecular basis of sperm capacitation.
Testicular sperm that have undergone spermatogeneis and spermiogenesis appear mature from a morphological standpoint but have acquired neither progressive motility nor the ability to fertilize a metaphase Il-arrested egg. In many species, progressive motility and fertilization competence are acquired during epididyma! transit, but complete fertilization capacity in vivo is only gained upon resi...
متن کاملBiological basis for syphilis.
Syphilis is a chronic sexually transmitted disease caused by Treponema pallidum subsp. pallidum. Clinical manifestations separate the disease into stages; late stages of disease are now uncommon compared to the preantibiotic era. T. pallidum has an unusually small genome and lacks genes that encode many metabolic functions and classical virulence factors. The organism is extremely sensitive to ...
متن کاملUnderstanding the molecular basis of sperm capacitation through kinase design.
T hirty years ago, on July 25, Steptoe and Edwards reported the birth of Louise Joy Brown, the first successful ‘‘Test-Tube’’ baby (1). This achievement followed a lack of success of in vitro fertilization experiments for almost 80 years since the first attempts in 1878. These early failures were due mainly to a lack of comprehension of sperm physiology. In the early 1950s, Chang (2) and Austin...
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ژورنال
عنوان ژورنال: Human Reproduction Update
سال: 2005
ISSN: 1460-2369,1355-4786
DOI: 10.1093/humupd/dmi010